Fig. 4

DLAT enhances glycolysis metabolism in NSCLC cells. A DLAT overexpression increased L-lactate production in PC9 cells. B DLAT up-regulation enhanced L-lactate production in A549 cells. C DLAT overexpression increased pyruvate release from PC9 cells. D Up-regulation of DLAT promoted pyruvate release from A549 cells. E Knockdown of DLAT suppressed L-lactate generation from PC9 cells. F Down-regulation of DLAT inhibited L-lactate generation from A549 cells. G Inhibition of DLAT expression decreased pyruvate production in PC9 cells. H Decreased DLAT expression reduced pyruvate production in A549 cells. I Overexpression of DLAT enhanced ECAR levels in PC9 cells. J Up-regulation of DLAT increased ECAR levels in A549 cells. *P < 0.05, **P < 0.01