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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

Fig. 2

Effects of C1GALT1 on malignant behavior of BLCA cells. A C1GALT1 expression in C1GALT1-silenced YTS-1 cells (termed shC#1–3) with/without Doxy treatment. B-D Proliferation of C1GALT1-silenced YTS-1 vs. control cells by CCK8 (B) and Edu assay (C, D). ***, p < 0.001. E, F Migratory ability (E) and colony formation (F) of C1GALT1-silenced YTS-1 vs. control cells. ***, p < 0.001. G-I Tumor size (G), weight (H), and volume (I) for mice injected with C1GALT1-silenced, ITZ-treated, and control YTS-1 cells (n = 7). *, p < 0.05; **, p < 0.01; ***, p < 0.001. J-L Tumor size (J), weight (K) and volume (L) for PDXs with/without ITZ treatment. M, N Microphotographs of splenic (M) and liver metastatic tumors (N). O A popliteal lymphatic metastasis model was established by inoculating the foot pads of nude mice with YTS-1 cells. P, Q Size of LNs (P) and metastasis ratios (Q) of popliteal lymphatic metastasis mouse model

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