Skip to main content
Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

Fig. 4

Methylation and transcription are largely preserved between primary and recurrent tumors from each patient, as shown by the expression of genes within partially methylated domains (PMDs): A Genes within PMDs shared by multiple tumor specimens are less expressed (left) but more variable in their expression (right) than genes outside of PMDs; B The vast majority of tumor suppressor genes in cancer and genes that form the ovarian cancer molecular subtypes defined by The Cancer Genome Atlas are located outside of PMDs; C Intra-patient pairwise Euclidean distances were significantly smaller than inter-patient distance or the intra-stage stage distance in both methylation (top) and gene expression (below) from paired RNA-Seq

Back to article page