Fig. 4From: DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancersMethylation and transcription are largely preserved between primary and recurrent tumors from each patient, as shown by the expression of genes within partially methylated domains (PMDs): AÂ Genes within PMDs shared by multiple tumor specimens are less expressed (left) but more variable in their expression (right) than genes outside of PMDs; BÂ The vast majority of tumor suppressor genes in cancer and genes that form the ovarian cancer molecular subtypes defined by The Cancer Genome Atlas are located outside of PMDs; CÂ Intra-patient pairwise Euclidean distances were significantly smaller than inter-patient distance or the intra-stage stage distance in both methylation (top) and gene expression (below) from paired RNA-SeqBack to article page