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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker

Fig. 4

Integrated aberrant alternative splicing event (AASE) landscape of OABL. A Workflow of AASE analysis. B UpSet plot showing intersections among the five types of AASEs in each patient. C Bar plot showing the number of the five types of AASEs and related genes. D Bar plot of top 20 enrichment terms identified in AASE-related genes. E Heatmap of top 20 enrichment terms correlated with Inclevel of AASEs identified by GSVA. Enrichment terms are ranked by the correlation score and shown in the orange bar. Count of high correlated AASEs with |r| > 0.6 is showed in blue bar. F Heatmap of top 20 splicing factors and regulators correlated with Inclevel of AASEs. G Forrest plot of top 15 progression-related AASEs ranked by p-value. Progression-related AASEs are calculated by cox regression. H Heatmap of top 20 splicing factors and regulators correlated with Inclevel of progression-related AASEs

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