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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker

Fig. 5

ADAR regulates key biological functions in OABL. A Bar plot of top 20 enrichment terms identified in ADAR highly correlated AASE genes (IrI > 0.6, p < 0.05). B Bar plot of top 20 enrichment terms identified in ADAR regulated AASE affected genes (frequency ≥ 2). C ADAR protein abundance is significantly positively correlated with MKI67 abundance in OABL. Blue line shows linear regression. D ADAR RNA expression level is significantly positively correlated with MKI67 level in most TCGA databases. Name of databases labeled with red/blue color if p < 0.05. Name of databases is bold if |r| > 0.4. E ADAR KD SU-DHL-4 and Raji exhibit decreased cell proliferation ability. F SU-DHL-4 and Raji cells with control ADAR knockdown are treated by Rho GTPase inhibitor MLS000532223 for 72 hours. ADAR knockdown cell lines exhibit lower IC50

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