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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Acylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39

Fig. 1

High expression of AGK correlated with EOC progression. A GO functional and pathway enrichment analysis of EOC specimens (T) compared to the adjacent noncancerous tissue samples (ANT). B A heatmap representing the genes upregulated in T compared to the adjacent ANT. 1 column represents 1 sample in different conditions. C Specimens derived from human EOC (T) were analyzed through IHC compared to the adjacent noncancerous tissue samples (ANT). AGK was upregulated in human EOC tissues. D RT-PCR and Western blotting were performed to analyze 4 matched pairs of EOC specimens (T) and adjacent noncancerous tissue samples (ANT). N = 3 independent experiments. E Kaplan-Meier overall survival curves (left panel), progression-free survival (right panel) and univariate analyses (log-rank) comparing patients with EOC with low (n = 48) and high (n = 92) AGK-expressing tumors. F The prognostic value of AGK in ovarian cancer series from publicly available datasets. Kaplan–Meier curves through a univariate analysis (log-rank) of patients with EOC and a high AGK expression (n = 1014) versus those with a low AGK expression (n = 421) for the overall survival (http://kmplot.com/analysis/index.php?p=service&cancer=ovar)

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