Fig. 1

The expression patterns and clinical significance of VEGFD in lung adenocarcinoma. A VEGFD mRNA expression patterns extracted from the database of The Human Protein Atlas. B VEGFD mRNA expression patterns in tumors extracted from the database of TCGA. C VEGFD mRNA expression patterns in lung adenocarcinoma extracted from the database of TCGA. D VEGFD protein expression patterns in lung adenocarcinoma extracted from the database of CPTAC. E Kaplan‑Meier survival curves of patients with lung adenocarcinoma expressing different levels of VEGFD gene from the database of Assistant for Clinical Bioinformatics. F, G VEGFD mRNA expression patterns in different stages and sites of tumor development extracted from the database of Assistant for Clinical Bioinformatics. H VEGFD protein level in different stages and sites of tumor development extracted from the database of CPTAC. I-J Lungs of urethane-induced lung tumors were used for sectioning, H&E staining, IHC for VEGFD, and their quantification. Numerical data were expressed as mean ± SD (each n = 3). K Western blot analyses for VEGFD in urethane-induced lung tumors. L-M Xenografts were used for sectioning, H&E staining, IHC for VEGFD, and their quantification. Numerical data were expressed as mean ± SD (each n = 3). N Western blot analyses for VEGFD in LLC cell xenografts. Data in (K) and (N) are representative of three independent experiments, and data in (J) and (M) represent the mean ± SEM of triplicate samples. *P < 0.05, **P < 0.01, Student’s t test