Fig. 1

A Supervised hierarchical clustering representing differentially expressed miRNAs before (baseline) and after (treatment) artichoke leaf extract treatment. Red and green colours show high and low standardized expression levels, respectively. B Principal component analysis representation of samples before (baseline) and after (treatment) artichoke leaf extract treatment obtained from the 11 miRNAs signature. C-D Boxplot analysis representing the distributions of the 11 miRNAs signature. Differences in the miRNA expression are evaluated by Wilcoxon test