Skip to main content

Table 3 HALLMARK pathways from MsigDB obtained using the web tool ShinyGO. The enrichment has been separately evaluated by considering predicted targets of the 11-miRNA signature (List AWPC) and of the 15-miRNA signature (List Derived from Comparison Benign vs Mesothelioma lesions)

From: Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial

List AWPC
Functional Category Enrichment FDR Genes in list Total genes
MSigDB:HALLMARK ESTROGEN RESPONSE EARLY 8.00E-10 168 197
MSigDB:HALLMARK MTORC1 SIGNALING 8.00E-10 168 197
MSigDB:HALLMARK IL2 STAT5 SIGNALING 3.00E-09 165 195
MSigDB:HALLMARK INFLAMMATORY RESPONSE 8.17E-08 163 197
MSigDB:HALLMARK UV RESPONSE DN 8.17E-08 121 141
MSigDB:HALLMARK APOPTOSIS 1.14E-07 134 159
MSigDB:HALLMARK APICAL JUNCTION 1.14E-07 160 194
MSigDB:HALLMARK ANDROGEN RESPONSE 2.77E-07 86 97
MSigDB:HALLMARK PI3K AKT MTOR SIGNALING 4.38E-07 91 104
MSigDB:HALLMARK P53 PATHWAY 7.97E-07 159 196
MSigDB:HALLMARK HYPOXIA 1.07E-06 157 194
MSigDB:HALLMARK PROTEIN SECRETION 1.07E-06 84 96
MSigDB:HALLMARK MITOTIC SPINDLE 2.00E-06 159 198
MSigDB:HALLMARK GLYCOLYSIS 2.00E-06 159 198
MSigDB:HALLMARK IL6 JAK STAT3 SIGNALING 3.65E-06 76 87
MSigDB:HALLMARK TNFA SIGNALING VIA NFKB 8.82E-06 157 198
MSigDB:HALLMARK KRAS SIGNALING UP 9.12E-06 154 194
MSigDB:HALLMARK UV RESPONSE UP 2.07E-05 124 154
MSigDB:HALLMARK E2F TARGETS 9.99E-05 152 196
MSigDB:HALLMARK DNA REPAIR 1.58E-04 112 141
MSigDB:HALLMARK HEME METABOLISM 2.76E-04 151 197
MSigDB:HALLMARK G2M CHECKPOINT 3.81E-04 149 195
MSigDB:HALLMARK EPITHELIAL MESENCHYMAL TRANSITION 8.43E-04 149 197
MSigDB:HALLMARK TGF BETA SIGNALING 1.17E-03 46 54
MSigDB:HALLMARK KRAS SIGNALING DN 1.23E-03 144 191
MSigDB:HALLMARK MYOGENESIS 1.62E-03 149 199
MSigDB:HALLMARK COMPLEMENT 1.76E-03 146 195
MSigDB:HALLMARK ESTROGEN RESPONSE LATE 1.77E-03 148 198
MSigDB:HALLMARK UNFOLDED PROTEIN RESPONSE 2.38E-03 85 109
MSigDB:HALLMARK CHOLESTEROL HOMEOSTASIS 2.60E-03 59 73
List Derived from Comparison Benign vs Mesothelioma lesions
Functional Category Enrichment FDR Genes in list Total genes
MSigDB:HALLMARK UV RESPONSE DN 5.89E-11 128 141
MSigDB:HALLMARK IL2 STAT5 SIGNALING 1.54E-10 169 195
MSigDB:HALLMARK KRAS SIGNALING UP 4.73E-10 167 194
MSigDB:HALLMARK ESTROGEN RESPONSE EARLY 1.61E-09 168 197
MSigDB:HALLMARK MTORC1 SIGNALING 3.40E-08 165 197
MSigDB:HALLMARK ADIPOGENESIS 6.19E-08 159 190
MSigDB:HALLMARK PI3K AKT MTOR SIGNALING 3.23E-07 92 104
MSigDB:HALLMARK APICAL JUNCTION 3.23E-07 160 194
MSigDB:HALLMARK INFLAMMATORY RESPONSE 3.23E-07 162 197
MSigDB:HALLMARK HEME METABOLISM 3.23E-07 162 197
MSigDB:HALLMARK ANDROGEN RESPONSE 4.47E-07 86 97
MSigDB:HALLMARK PROTEIN SECRETION 5.62E-07 85 96
MSigDB:HALLMARK APOPTOSIS 1.38E-06 132 159
MSigDB:HALLMARK P53 PATHWAY 1.74E-06 159 196
MSigDB:HALLMARK TNFA SIGNALING VIA NFKB 2.41E-06 160 198
MSigDB:HALLMARK COMPLEMENT 4.42E-06 157 195
MSigDB:HALLMARK HYPOXIA 5.18E-06 156 194
MSigDB:HALLMARK EPITHELIAL MESENCHYMAL TRANSITION 5.69E-06 158 197
MSigDB:HALLMARK MYOGENESIS 1.66E-05 158 199
MSigDB:HALLMARK IL6 JAK STAT3 SIGNALING 1.82E-05 75 87
MSigDB:HALLMARK UV RESPONSE UP 1.82E-05 125 154
MSigDB:HALLMARK GLYCOLYSIS 1.39E-04 154 198
MSigDB:HALLMARK KRAS SIGNALING DN 1.39E-04 149 191
MSigDB:HALLMARK MITOTIC SPINDLE 2.53E-04 153 198
MSigDB:HALLMARK ESTROGEN RESPONSE LATE 4.51E-04 152 198
MSigDB:HALLMARK OXIDATIVE PHOSPHORYLATION 5.38E-04 141 183
MSigDB:HALLMARK PEROXISOME 7.41E-04 83 103
MSigDB:HALLMARK APICAL SURFACE 9.05E-04 38 43
MSigDB:HALLMARK G2M CHECKPOINT 1.16E-03 148 195
MSigDB:HALLMARK DNA REPAIR 1.78E-03 109 141