Skip to main content

Table 3 Univariate and Multivariate Analysis of YAP1/FAPα and Clinical Characteristics for Overall Survival of NPC Patients

From: Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts

YAP1 Univariate analysis   Multivariate analysis  
n = 106 HR (95% CI) p value HR (95% CI) p value
YAP1 Score (≥80 vs. < 80) 1.447 (0.782–2.679) 0.239 2.402 (1.218–4.737) 0.011
Treatment Daysa 1.074 (0.999–1.156) 0.053 1.142 (1.049–1.242) 0.002
BEDa 0.982 (0.882–1.093) 0.737 0.887 (0.791–0.995) 0.04
Age Group (≥48 vs. < 48) 1.086 (0.587–2.009) 0.792 0.632 (0.288–1.389) 0.253
Gender (Male vs. Female) 2.412 (1.014–5.738) 0.046 3.657 (1.356–9.862) 0.01
T-Stage (T3/4 vs. T1/2) 1.956 (1.034–3.701) 0.039 3.584 (1.579–8.139) 0.002
N-Stage (N2/3 vs. N0/1) 1.394 (0.752–2.582) 0.291 1.554 (0.787–3.069) 0.204
Chemotherapy (Yes vs. No) 0.901 (0.449–1.911) 0.77 1.180 (0.515–2.706) 0.696
Comorbidity (Yes vs. No) 1.923 (1.041–3.551) 0.037 3.277 (1.493–7.190) 0.003
Smoking (Yes vs. No) 1.417 (0.756–2.658) 0.277 0.945 (0.453–1.971) 0.879
Betel quid (Yes vs. No) 1.707 (0.870–3.348) 0.12 0.980 (0.408–2.355) 0.964
Alcohol (Yes vs. No) 1.361 (0.733–2.527) 0.329 1.286 (0.588–2.812) 0.528
FAPα Univariate analysis   Multivariate analysis  
n = 143 HR (95% CI) p value HR (95% CI) p value
FAPα Score (≥80 vs. < 80) 1.248 (0.890–2.259) 0.463 1.009 (0.521–1.953) 0.979
Treatment Daysa 1.044 (0.988–1.103) 0.129 1.039 (0.978–1.104) 0.212
BEDa 1.007 (0.939–1.081) 0.837 0.965 (0.887–1.049) 0.403
Age Group (≥48 vs. < 48) 1.456 (0.804–2.635) 0.215 1.340 (0.691–2.596) 0.386
Gender (Male vs. Female) 1.338 (0.681–2.631) 0.398 1.364 (0.623–2.990) 0.437
T-Stage (T3/4 vs. T1/2) 2.610 (1.403–4.855) 0.002 3.324 (1.603–6.894) 0.001
N-Stage (N2/3 vs. N0/1) 1.313 (0.738–2.338) 0.354 1.257 (0.672–2.351) 0.474
Chemotherapy (Yes vs. No) 0.766 (0.401–1.463) 0.419 0.525 (0.243–1.133) 0.101
Comorbidity (Yes vs. No) 1.432 (0.797–2.570) 0.23 1.686 (0.872–3.263) 0.121
Smoking (Yes vs. No) 1.046 (0.587–1.864) 0.878 0.893 (0.437–1.824) 0.757
Betel quid (Yes vs. No) 1.555 (0.831–2.909) 0.167 1.837 (0.867–3.893) 0.112
Alcohol (Yes vs. No) 0.978 (0.523–1.831) 0.946 0.716 (0.327–1.568) 0.404
  1. acontinuous variable. BED Biologically effective dose, HR Hazard ratio, CI Confidence interval