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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway

Fig. 6

The expression and correlation analysis between lncMMPA and glycolysis components in CRC patients. A Correlation analysis between lncMMPA expression and miR-548 s expression in HCC tissues of ZSHS cohort 2; n = 40. B Representative immunohistochemical (IHC) staining for ALDH1A3 in HCC cancer samples with lncMMPA low and miR-548 s high or lncMMPA high and miR-548 s low expression level of ZSHS cohort 1; n = 108. Scale bar, 50 μm. C Correlation analysis between lncMMPA expression and ALDH1A3 in HCC tissues, n = 424, in TCGA LIHC dataset. D Correlation analysis between lncMMPA expression and ALDH1A3 expression in HCC tissues of ZSHS cohort 3; n = 117. E Correlation analysis between lncMMPA expression and miR548s expression in HCC tissues of ZSHS cohort 3; n = 117. F Correlation analysis between ALDH1A3 expression and miR548s expression in HCC tissues of ZSHS cohort 3; n = 117. G Survival was determined and compared between patients showing high and low levels of lncMMPA expression in the tumor, in ZSHS cohort 3; n = 117, log-rank test. H Survival was assessed and compared between patients showing high and low levels of ALDH1A3 expression in the tumor in ZSHS cohort 3; n = 117, log-rank test. I Survival was analyzed and compared among HCC patients based on the number of upregulated molecular markers (lncMMPA and ALDH1A3) in ZSHS cohort 3; n = 117. J Potential schematic pathway illustrated the role of lncMMPA in HCC progression

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