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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription

Fig. 4

circCCDC134 contributes to abnormal gene expression in CC. A and B Heatmap of mRNA-seq data of CC and metastatic tissues. C and D Heatmap and scatterplot results of si-circCCDC134 mRNA-seq data. E and F KEGG and GSEA based on si-circCCDC134 mRNA-seq data. G GSEA of the TNF signalling pathway. H and I Identification of potential TNF and EMT mRNAs regulated by circCCDC134. J Heatmap of TNF and EMT mRNAs regulated by circCCDC134. K and L The expression of EFNA1 was decreased in ME180 and SiHA cells and increased in HCC94 cells that were induced by circCCDC134. KLF2, PER1 and COL5A3 expression was increased in ME180 and SiHA cells and decreased in HCC94 cells induced by circCCDC134

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