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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer

Fig. 6

Drug combination inhibits multiple molecules in Wnt/β-catenin signaling pathway in ACC: SW13 and NCI-H295R cells were treated with OTS167, RGB-286638, and a combination of OTS167 and RGB-286638. Western blot analysis for β-catenin, AXIN2, GSK3α/β, and FOXM1 expression in SW13 cells treated for 24–48 h and NCI-H295R cells treated for 48–72 h with OTS167, RGB-286638, and OTS167 and RGB-286638 combined is shown

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