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Fig 1 | Journal of Experimental & Clinical Cancer Research

Fig 1

From: The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

Fig 1

NLGN1 expression in human colorectal cancer. A Tatsuky plot displaying the Z-Score distribution of NLGN1 in CRC primary tumors (TCGA, PanCancer Atlas). Red dots indicate the samples with Z-Scores above 1.6. B, C Kaplan-Maier plots showing that higher NLGN1 expression predicts worse overall survival (B) and disease free survival (C) in CRC patients from cBioportal. P value was calculated as logrank test. D-F IHC was performed to evaluate NLGN1 expression on a TMA of colorectal cancer (CRM1505 - Biomax), which contains the following specimens: 88 cases of adenocarcinoma, 29 mucinous adenocarcinoma, 10 tubular adenocarcinoma, 4 tubular adenocarcinoma partly mucinous, 6 tubular+papillary adenocarcinoma and 4 adenosquamous adenocarcinoma, single cores per case. D Distribution of NLGN1 protein expression according to the IHC positivity (present or absent) in terms of pathology diagnosis. NLGN1 is mainly expressed in human adenocarcinoma. E. Distribution of NLGN1 protein expression among cores from human adenocarcinoma according to the IHC score, as present (1, 2, 3) or absent (0). NLGN1 is expressed at a higher percentage and intensity in cores from tumor grade 2. F Representative images of NLGN1 protein expression by IHC in CRC TMA cores and their relative score (original magnification 10X). G-I Representative images of NLGN1 expression in human CRC from a patient case study available in our institute. Immunohistochemistry reactions with antibodies anti-NLGN1 showed intense, diffuse positivity in a subset of colon adenocarcinoma. Moreover, NLGN1 positivity was even stronger in single-cell high grade budding (G) and in vascular neoplastic emboli (H-I). Scale bar: 10 μm

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