Fig. 4

Knockdown of circARID1A inhibits the proliferation of GC in vitro and in vivo. A Cell viability of SGC7901 and BGC823 cells following circARID1A knockdown. B-C (B) Plate colony formation and (C) EdU assays of SGC7901 and BGC823 cells following circARID1A knockdown. D Efficiency of lentivirus sh-circARID1A transduction in SGC7901 cells. E Cell viability of SGC7901 cell following circARID1A stable knockdown. F Plate colony formation assay of SGC7901 cells with circARID1A stable knockdown. G Images of xenograft GC tumors with circARID1A knockdown. H Tumor volumes of xenograft GC tumors at different times. I Tumor weights of xenografts evaluated after mouse sacrifice. J CircARID1A expression in xenografted tumor tissues. K Representative images of Ki-67 expression evaluated by IHC in xenografted tumor tissues. Three different visual fields were randomly selected for each slice. The P-values were calculated using the two-tailed Student’s t test. *P < 0.05