Fig. 8

CircARID1A promotes the proliferation of GC by upregulating SLC7A5. A Expression of SLC7A5 in 12 paired GC tissues. B CCK-8 assay of SGC7901 and BGC823 cells following SLC7A5 knockdown. C-D (C) EdU and (D) plate colony formation assays in SGC7901 and BGC823 cells following SLC7A5 knockdown. E–F The expression of SLC7A5 (E) mRNA and (F) protein in SGC7901 cells transfected with vector or SLC7A5 and those co-transfected with NC or si-circARID1A. G-H (G) CCK-8 or (H) plate colony formation assay of SGC7901 cells transfected with vector or SLC7A5 and those co-transfected with NC or si-circARID1A as indicated. I In vivo analyses of tumor in mice that were subcutaneously implanted with HGC-27 cells and injected with Negative control, cholesterol-modified si-circARID1A combined with or without lentivirus containing SLC7A5. The P-values were calculated by two-tailed Student’s t test or one way ANOVA. *P < 0.05