Fig. 2

SLERCC is downregulated in RCC tissues. A The process of gene microarray. B, C The heatmap and volcano plot of differentially expressed genes. D The expression levels and chromosome positions of the differentially expressed genes. E Expression of SLERCC in normal (n = 72) and tumor (n = 539) tissues in TCGA dataset. F Relative expression of SLERCC in 90 paired tissue samples in our clinical data. G, H Relative expression levels of SLERCC in tissue samples for tumor Fuhrman grade (G) and N stage (H) in our clinical data. I Relative expression of SLERCC in 50 paired tissue samples in our clinical data. J, K Overall survival (J) and disease-free survival (K) curves for RCC patients with low and high SLERCC expression in TCGA dataset. L Univariate and multivariate Cox regression of OS for SLERCC and other clinicopathological features in TCGA dataset. M GSEA analysis of different SLERCC expression levels. (**p < 0.01, ***p < 0.001). Abbreviations: OS, Overall survival; DFS, Disease-free survival; TCGA, The Cancer Genome Atlas; RCC, Renal cell carcinoma