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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology

Fig. 2

Rapidly progressing vestibular schwannoma has an enrichment of genes associated with innate immune cell activation. A Heatmap showing 44 genes differentially expressed (p < 0.01) between vestibular schwannoma patients with early (red) and late (blue) recurrence. Gene expression levels are represented in log2 scale. B Principal component analysis with the same set of 44 genes confirmed that tumors from patients with early recurrence and those from patients with late recurrence have distinct gene expression profiles. C The Bubble plot shows KEGG and Reactome pathways significantly enriched by the 44 differentially expressed genes (DEG) between the early- and late-recurrence VS groups (left y-axis). Enrichment corrected p-values were -log10 − transformed for representation (right y-axis). Each DEG associated with the depicted enriched pathways are represented by a bubble, in which their color and size represents the gene log2 fold-change and -log10 transformed p-values obtained from VS group comparison. D The Bubble plot shows Gene Ontology (GO) terms significantly enriched by the 44 differentially expressed genes (DEG) between the early- and late-recurrence VS groups (left y-axis). Enrichment corrected p-values were -log10 − transformed for representation (right y-axis). Each DEG associated with the depicted enriched pathways are represented by a bubble, in which their color and size represents the gene log2 fold-change and -log10 transformed p-values obtained from VS group comparison

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