Fig. 3

Pathways significantly enriched in rapidly progressing vestibular schwannoma. A Ingenuity Pathway Analysis (IPA) canonical pathways predicted to be activated (positive z-score) in early recurrent VS patients. The predicted level of pathway activation (z-score) is represented by bar color and its activation significance level (-log₁₀ transformed p-value) by bar length (y-axis). B IPA canonical pathways predicted to be inhibited (negative z-score) in early-recurrent VS patients. The predicted level of pathway inhibition (z-score) is represented by bar color and its activation significance level (-log₁₀ transformed p-value) by bar length (y-axis). C IPA Disease & Function terms predicted as significantly activated (positive z-score; x-axis) and inhibited (negative z-score; x-axis) among early recurrent VS patients. Significance levels are represented by bar color (-log₁₀ transformed p-value)