Fig. 4

ETV1 promotes HCC metastasis by upregulating PTK2 and c-MET. (A) The levels of ETV1, PTK2, and c-MET in HCC cells after transfected with indicated lentivirus. (B) The migratory and invasive capacity were determined by transwell assays in the indicated HCC cells. (C-H) In vivo metastatic assay. (C) The representative BLI images in the liver were shown 9 weeks after implantation with indicated cells. (D) The bioluminescent signals were used to show the growth rate of liver tumors. (E) The number of metastatic lesions in the lung tissues. (F) The occurrence of lung metastasis. (G) The OS of different groups of nude mice. (H) Representative images of H&E staining of lung samples (indicated by arrowheads) from each group. * Represented p < 0.05. All data were displayed as Mean ± SD