HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET

Table 1 Correlation between ETV1 expression and clinicopathological characteristics of HCCs in two independent cohorts of human HCC tissues

Clinicopathological variables		Tumor ETV1 expression		P Value	Tumor ETV1 expression		P Value
Clinicopathological variables		Negative (n = 151)	Positive (n = 109)	P Value	Negative (n = 154)	Positive (n = 126)	P Value
Age		52.11	51.77	0.411	50.57	51.51	0.351
Age		(11.915)	(10.417)		(10.053)	(9.743)
Sex	female	31	18	0.428	19	25	0.100
Sex	male	120	91		135	101
Serum AFP	≤ 20 ng/ml	46	21	0.045	32	23	0.652
Serum AFP	> 20 ng/ml	105	88		122	103
Virus infection	HBV	108	84	0.523	119	106	0.406
	HCV	14	11		11	8
	HBV + HCV	9	3		11	4
	none	20	11		13	8
Cirrrhosis	absent	40	32	0.674	42	34	1.000
Cirrrhosis	present	111	77		112	92
Child–pugh score	Class A	113	83	0.884	130	103	0.630
Child–pugh score	Class B	38	26		24	23
Tumor number	single	91	63	0.703	124	86	0.026
Tumor number	multiple	60	46		30	40
Maximal tumor size	≤ 5 cm	69	39	0.126	102	56	< 0.001
Maximal tumor size	> 5 cm	82	70		52	70
Tumor encapsulation	present	95	50	0.008	118	77	0.006
Tumor encapsulation	absent	56	59		36	49
Microvascular invasion	absent	97	45	< 0.001	97	56	0.003
Microvascular invasion	present	54	64		57	70
Tumor differentiation	I-II	131	75	0.001	132	77	< 0.001
Tumor differentiation	III-IV	20	34		22	49
TNM stage	I-II	128	70	< 0.001	136	82	< 0.001
TNM stage	III	23	39		18	44

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