Skip to main content
Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Fig. 5

PCSK9 activation of the PI3K/AKT signaling in colon cancer cells in vitro. a–f, Western blot. HCT116 and HT-29 cells were grown and transiently transfected with PCSK9 or control siRNA or with plasmids carrying PCSK9 cDNA or vector only, and then subjected to Western blot analysis of p-PI3K, p-AKT, and AKT expression (c and d, PCSK9 knockdown; e and f, PCSK9 overexpression). NC, negative control; KD, knockdown of PCSK9 cells transfected with PCSK9 siRNA; OE, overexpression of PCSK9 cells transfected with plasmids carrying PCSK9 cDNA. *p < 0.05, **p < 0.01; ***p < 0.001; ns, no significance

Back to article page