Fig. 2

MET-CAR-T killing activity on human cells expressing different levels of the MET receptor at the cell surface. MET-CAR-T specific killing activity at different Effector:Target ratio versus: (A) wild type A549 human lung carcinoma cells (A549_wt); (B) A549 cells genetically modified to overexpress the MET receptor (A549_MET⁺); (C) A549 cells genetically modified to abrogate the expression of the MET receptor (A549_koMET); (D) Huvec, human umbilical vein endothelial cells; (E) human primary keratinocytes; (F) 293 T, not-transformed human kidney epithelial cells; (G) human primary fibroblasts. NTD: Not-transduced T cells, #948/#949: MET-CAR-T. Bars: Standard Deviations. Statistical significance between NTD and MET-CAR-T was calculated by Two-way Anova, corrected Bonferroni. Stars indicated P values: **, P ≤ 0.01; ****, P ≤ 0.0001