Skip to main content
Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Fig. 2

Comparative 3D SIM imaging of the localization of AKTIP in tumor cells (A) Projections of an extended section of Hela, A549 and MCF7 nuclei labelled with anti-lamin A/C and anti-AKTIP antibodies, viewed from orthogonal planes and magnified sections. B Pearson correlation coefficient of the co-localization between AKTIP and lamin A/C in A549 and MCF7 and HeLa cells. C Projections of an extended section of Hela, A549 and MCF7 nuclei labelled with anti-lamin B1 and anti-AKTIP antibodies, viewed from orthogonal planes and magnified sections. D Quantification of AKTIP foci distribution in HeLa, A549 and MCF7 cells measured as the percentage of AKTIP positive rim. In B and D each dot corresponds to a nucleus. A minimum of 7 nuclei were counted for each cell line. Mean ± SEM are shown. * p < 0.05, ** p < 0.01 in unpaired Student t-test, ***p < 0.001 in unpaired Student t-test

Back to article page