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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Fig. 3

Comparative 3D SIM imaging of the localization of AKTIP in non-transformed laminopathic cells (A) Projections of an extended section of non-transformed wild type, HGPS and EDMD2 patient derived fibroblast nuclei labelled with anti-lamin A/C and anti-AKTIP antibodies, viewed from orthogonal planes and magnified sections. B Pearson correlation coefficient to measure the co-localization between AKTIP and lamin A/C in wild type, HGPS and EDMD2 cells. C Projections of an extended section of non-transformed wild type, HGPS and EDMD2 nuclei labelled with anti-lamin B1 and anti-AKTIP antibody, viewed from orthogonal planes and magnified sections. D Percentage of AKTIP positive rim in wild type, HGPS and EDMD2 cells. In B and D each dot corresponds to a nucleus. A minimum of 7 nuclei were counted for each cell type. Mean ± SEM are shown. ***p < 0.001 in unpaired Student t-test

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