Skip to main content
Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Fig. 6

Correlation analysis of AKTIP localization with lamin expression and morphometric index. A-C AKTIP localization at the rim, expressed as the percentage of AKTIP positive rim, does not significantly correlate with lamin mRNA levels quantified by RT Q-PCR. D, E Correlation between percentage of AKTIP positive rim and lamin A and lamin C expression quantified by Western Blotting. F Inverse correlation between AKTIP localization at the rim and morphometric index, calculated for each nucleus as the sum of the differences between each morphometric index and their mean value in wild type non-transformed fibroblasts. G Correlation between AKTIP positioning at the rim and cumulative parameter obtained merging for each type the ratio between lamin A and lamin C proteins levels from WB quantification and morphometric index as in F proteins ratio and morphometric index. In F each dot corresponds to a nucleus. In A-E, and G mean values ± SEM are shown. Linear regression values are shown

Back to article page