Skip to main content
Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression

Fig. 2

FIP-1 binds to FOXM1 and inhibits viability of cancer cells. A Screening and identification of FOXM1 targeted peptides using an in vitro phage display. B Name and sequence of FOXM1 targeted peptides. C Effect of three rounds of screening peptides was verified by CCK8 in HepG2 cells. D Peptides were renamed after labeling the TAT sequence at the C-terminal. E Viability of cells, treated with three screened peptides for 24 h, were performed using CCK-8, and the results showed that FIP-1 inhibited the growth of HepG2 cells. F Localization of FOXM1 (red) and FITC-labeled FIP-1 (green) was imaged with fluorescent Con-focal microscopy. Cell nuclei was stained by DAPI (blue). Lift: F-1, Right: FIP-1. G The level of cellular uptake was quantified with flow cytometry

Back to article page