Skip to main content

Table 1 The components of basement membrane and interstitial matrices, and their implication in ECM

From: The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?

Matrix ECM component Interact with: Cell surface receptors References
Basement membrane Collagen IV Laminin, Nidogen, Perlecan, proteoglycans and growth factors (TGFβ1, PDGF) Integrins and DDR1 [12, 13]
Laminins Collagen, laminins, nidogens and perlecan, plasminogen, agrin, sulfatides, immunoglobulins and plectin, plasminogen activator and axon guidance molecules Cell surface collagens (collagen XVII), dystroglycan, integrins and syndecans [13, 14]
Perlecan Growth factors (FGF, bFGF, VEGF), collagen IV, antithrombin III, sulfatides, laminins, nidogens, fibulins, fibronectin, thrombospondins and prolargin Integrins [15, 16]
Nidogen/ entactin Collagen IV, laminins, fibulin 1 and perlecan Integrins [13, 17]
Interstitial matrices Collagen I Cytokines (IL2, oncostatin M), growth factors (PDGF, KGF), collagens, fibronectin, proteoglycans Syndecans, integrins, DDR1 and DDR2 [18]
Elastin Fibrillin, fibulins, elastins, EBP Integrin Vβ3 [19]
Fibronectin Growth factors (PDGF, VEGF, FGF), phospholipids, gangliosides, acetylcholinesterase, factor XIIIa transglutaminase, fibrinogen, fibronectin, fibrin, collagens, fibulin-1, proteoglycans, thrombospondins, factor VIII Syndecans and integrins [20, 21]
Proteoglycans Growth factors (TGFβ, FGF, VEGF), morphogens (Wnt, BMP), cytokines (CCL2), fibronectin, collagens, laminins, tenascins Growth factor receptors (VEGFR), L1CAM, integrins [22]
Tenascins Growth factors (VEGF), cytokines (IL8), collagen, fibronectin, proteoglycans Growth factors receptors (EGFR), integrins, cell surface annexin II [23]
  1. DDR1 Discoidin domain-containing receptor 1, DDR2 Discoidin domain-containing receptor 2, TGFβ Transforming growth factor β, PDGF Platelet-derived growth factor, FGF Fibroblast growth factor, bFGF Basic fibroblast growth factor, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, L1CAM L1 cell adhesion molecule, KGF Keratinocyte growth factor, IL2 Interleukin-2, EBP Elastin-binding protein, CCL2 C–C motif chemokine ligand 2, BMP Bone morphogenetic protein, EGFR Epidermal growth factor receptor