Table 1 The components of basement membrane and interstitial matrices, and their implication in ECM

Basement membrane

Collagen IV

Laminin, Nidogen, Perlecan, proteoglycans and growth factors (TGFβ1, PDGF)

Integrins and DDR1

[12, 13]

Laminins

Collagen, laminins, nidogens and perlecan, plasminogen, agrin, sulfatides, immunoglobulins and plectin, plasminogen activator and axon guidance molecules

Cell surface collagens (collagen XVII), dystroglycan, integrins and syndecans

[13, 14]

Perlecan

Growth factors (FGF, bFGF, VEGF), collagen IV, antithrombin III, sulfatides, laminins, nidogens, fibulins, fibronectin, thrombospondins and prolargin

Integrins

[15, 16]

Nidogen/ entactin

Collagen IV, laminins, fibulin 1 and perlecan

Integrins

[13, 17]

Interstitial matrices

Collagen I

Cytokines (IL2, oncostatin M), growth factors (PDGF, KGF), collagens, fibronectin, proteoglycans

Syndecans, integrins, DDR1 and DDR2

[18]

Elastin

Fibrillin, fibulins, elastins, EBP

Integrin Vβ3

[19]

Fibronectin

Growth factors (PDGF, VEGF, FGF), phospholipids, gangliosides, acetylcholinesterase, factor XIIIa transglutaminase, fibrinogen, fibronectin, fibrin, collagens, fibulin-1, proteoglycans, thrombospondins, factor VIII

Syndecans and integrins

[20, 21]

Proteoglycans

Growth factors (TGFβ, FGF, VEGF), morphogens (Wnt, BMP), cytokines (CCL2), fibronectin, collagens, laminins, tenascins

Growth factor receptors (VEGFR), L1CAM, integrins

[22]

Tenascins

Growth factors (VEGF), cytokines (IL8), collagen, fibronectin, proteoglycans

Growth factors receptors (EGFR), integrins, cell surface annexin II

[23]