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Table 1 The components of basement membrane and interstitial matrices, and their implication in ECM

From: The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?


ECM component

Interact with:

Cell surface receptors


Basement membrane

Collagen IV

Laminin, Nidogen, Perlecan, proteoglycans and growth factors (TGFβ1, PDGF)

Integrins and DDR1

[12, 13]


Collagen, laminins, nidogens and perlecan, plasminogen, agrin, sulfatides, immunoglobulins and plectin, plasminogen activator and axon guidance molecules

Cell surface collagens (collagen XVII), dystroglycan, integrins and syndecans

[13, 14]


Growth factors (FGF, bFGF, VEGF), collagen IV, antithrombin III, sulfatides, laminins, nidogens, fibulins, fibronectin, thrombospondins and prolargin


[15, 16]

Nidogen/ entactin

Collagen IV, laminins, fibulin 1 and perlecan


[13, 17]

Interstitial matrices

Collagen I

Cytokines (IL2, oncostatin M), growth factors (PDGF, KGF), collagens, fibronectin, proteoglycans

Syndecans, integrins, DDR1 and DDR2



Fibrillin, fibulins, elastins, EBP

Integrin Vβ3



Growth factors (PDGF, VEGF, FGF), phospholipids, gangliosides, acetylcholinesterase, factor XIIIa transglutaminase, fibrinogen, fibronectin, fibrin, collagens, fibulin-1, proteoglycans, thrombospondins, factor VIII

Syndecans and integrins

[20, 21]


Growth factors (TGFβ, FGF, VEGF), morphogens (Wnt, BMP), cytokines (CCL2), fibronectin, collagens, laminins, tenascins

Growth factor receptors (VEGFR), L1CAM, integrins



Growth factors (VEGF), cytokines (IL8), collagen, fibronectin, proteoglycans

Growth factors receptors (EGFR), integrins, cell surface annexin II


  1. DDR1 Discoidin domain-containing receptor 1, DDR2 Discoidin domain-containing receptor 2, TGFβ Transforming growth factor β, PDGF Platelet-derived growth factor, FGF Fibroblast growth factor, bFGF Basic fibroblast growth factor, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, L1CAM L1 cell adhesion molecule, KGF Keratinocyte growth factor, IL2 Interleukin-2, EBP Elastin-binding protein, CCL2 C–C motif chemokine ligand 2, BMP Bone morphogenetic protein, EGFR Epidermal growth factor receptor