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Table 2 EMT-related long non-coding RNAs

From: Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

lncRNAs

Mode of action

EMT component

References

Related to EMT-transcription factors

 lncRNA-ATB, MAGI1-IT1, lncRNA-XIST, LINC00115, H19, lncRNA-PNUTS, lncRNA-PTAR, ZFAS1, OIP5-AS1, SNHG14, SNHG16

Sponging miRNA

ZEB1/2

[75, 76, 79,80,81,82,83,84,85,86,87,88]

 lncRNA RP11–138 J23.1

Post-translationally

[77]

 ZEB1-AS1

Epigenetically

[72, 89]

 lncRNA-BX111887

Transcriptionally

[74]

 lncRNA PVT1

Transcriptionally

SLUG

[90]

 AC026904.1

Enhancer RNA

[91]

 lncRNA GCMA, lncRNA TINCR, UCA1,

Sponging miRNA

[91,92,93]

 SNHG15

Post-translationally

[94]

 lncRNA GCMA, lncRNA-MUF, SNHG7

Sponging miRNA

SNAIL

[92, 95, 96]

 SATB2-AS1

Epigenetically

[97]

 lncRNA JPX, LINC01296

Sponging miRNA

TWIST1

[98, 99]

Related to cell adhesion and cytoskeletal components

 MALAT1, UCA1, TRERNA1, MEG3, ZNF667-AS1, SSTR5-AS1, SNHG20

Epigenetically

E-cadherin

[100,101,102,103,104,105,106]

 MEG3,

Sponging miRNA

[107, 108]

 NEAT1

Transcriptionally

ZO1

[109]

 MALAT1, H19

Sponging miRNA

vimentin

[79, 110]

 LINC00675, FTX, AOC4P

Post-translationally

[111,112,113]

Related to EMT signaling pathways

 lncRNA-ATB, lncRNA-XIST, LINC01278, OIP5-AS1

Sponging miRNA

TGF-β pathway components

[114,115,116,117]

 MIR22HG

Protein interaction

[118]

 TGFB2-AS1

Epigenetically

[119]

 MALAT1

Post-translationally

[120]

 lncRNA HERES, NEAT1, GATA6-AS1

Epigenetically

WNT pathway components

[121,122,123]

 MIR100HG, lincRNA-p21,

Post-transcriptionally

[124, 125]

 CYTOR, lncRNA-MUF, LncCCAT1

Post-translationally

[95, 126, 127]

 LncCCAT1, SNHG5, SNHG6

Sponging miRNA

[127,128,129]

Related to cell motility

 lncRNA-UCA1

Sponging miRNA

FSCN1

[130]

 lncMER52A

Post-translationally

p120-catenin

[131]

 LCAT1, H19, MALAT1, NORAD, XIST, CTC-497E21.4, TP73-AS1, AURKAPS1, FTH1P3

Sponging miRNA

Rho GTPase components

[132,133,134,135,136,137,138,139,140]