Fig. 7From: Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activationGSDMB acts as an autophagy adaptor in response to anti-HER2 therapies. Representative scheme of the proposed mechanism of action of GSDMB as mediator of protective autophagy response. It is highlighted the dualistic model on HER2/GSDMB over-expressing tumors behavior after the treatment anti-HER2 therapy (resistance phenotype) or its combination with autophagy inhibitors (sensible phenotype)Back to article page