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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation

Fig. 7

GSDMB acts as an autophagy adaptor in response to anti-HER2 therapies. Representative scheme of the proposed mechanism of action of GSDMB as mediator of protective autophagy response. It is highlighted the dualistic model on HER2/GSDMB over-expressing tumors behavior after the treatment anti-HER2 therapy (resistance phenotype) or its combination with autophagy inhibitors (sensible phenotype)

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