Fig. 5

In vivo imaging evaluation of DC-iMB. a Bioluminescence images acquired at multiple time points during the treatments to assess therapeutic responses. b Representative B-mode US (top) and non-linear contrast images of a spleen pre-injection (middle) and post-injection (bottom) with DC-iMBs, conventional MBs, or PBS. Scale bar = 3 mm. c Quantification of tumor bioluminescence signal over time. d Quantification of US signal enhancement pre- and post- MBs, DC-iMBs, or PBS injection. CEUS: contrast enhanced ultrasound. ***p < 0.0001