Skip to main content

Table 2 In vitro inhibitory effect of A2aR antagonists on intracellular cAMP accumulation stimulated by adenosine or NECA

From: Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist

  

Adenosine

NECA

 

Conc. (µM)

1

100

0.1

10

IC50 (nM)

DZD2269

0.10 ± 0.01

(n = 6)

24 ± 4.6

(n = 6)

0.14 ± 0.05

(n = 6)

28 ± 4.2

(n = 6)

CPI-444

15 ± 7.0

(n = 6)

5831 ± 1881

(n = 6)

23 ± 3.8

(n = 6)

5653 ± 702

(n = 6)

AZD4635

29 ± 11

(n = 4)

6314 ± 1691

(n = 4)

40 ± 5.9

(n = 4)

6534 ± 740

(n = 3)

AB928

3.4 ± 0.92

(n = 3)

463 ± 90

(n = 3)

4.1 ± 1.2

(n = 3)

408 ± 25

(n = 3)

  1. CHO-A2aR cells were stimulated with different concentrations of adenosine or NECA. cAMP was used as a readout. Values are expressed as average ± SD of independent experiments
Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us