Fig. 7

Effect of inhibition of miR-130b-3p on the growth of HNSCC PDX models. A Clinical characteristics of donor patients. B Graphic illustration of the generation of HNSCC PDX mouse models. C miR-130b-3p levels in the donor HNSCC tissues and paired ANM tissues were measured by qRT-PCR. D Representative IHC images of p-S6 staining from ANM or tumor tissues of donor patients. Scale bar, 50 μm. E–G PDX model tumors (n = 5 mice/group) treated with antagomiR-130b-3p (10 nmol/50 μL) or antagomiR-NC. E Tumor images. Scale bar, 1 cm. F Tumor volume. G Tumor weight. H miR-130-3p levels in the indicated tumor tissues were determined by qRT-PCR. I Representative HE and IHC staining for CD31, MBNL1, and p-STAT3 in the indicated PDX model tumors. Scale bar, 50 μm. Data indicate mean ± SD of 3–5 replicates. ** P < 0.01; *** P < 0.001