EGFR-dependent aerotaxis is a common trait of breast tumour cells

Mikaelian, Ivan; Gadet, Rudy; Deygas, Mathieu; Bertolino, Philippe; Hennino, Anca; Gillet, Germain; Rimokh, Ruth; Berremila, Sid-Ali; Péoc’h, Michel; Gonzalo, Philippe

doi:10.1186/s13046-022-02514-y

Journal of Experimental & Clinical Cancer Research

Table 1 Clinical details of breast tumours

From: EGFR-dependent aerotaxis is a common trait of breast tumour cells

Tumour Number	age (year)	TNM ⁽¹⁾	Cancer type [10]	Grading SBR ⁽²⁾	Tumour size (cm)	Volume (cm3)	Mitotic activity ⁽³⁾	Ki67 ⁽⁴⁾	HER2 ⁽⁵⁾	ER ⁽⁶⁾	PR ⁽⁷⁾
T4	65.7	pT2 N2 Mx	Pleomorphic invasive lobular carcinoma + NST⁽*⁾	3 (D3, A3, M2)	5 × 3 × 3	45.0	4.0	30%	-	-	-
T5	66.9	pT2 N1 Mx	NST⁽*⁾	3 (D3, A3, M2)	2.7 × 2.5 × 2	13.5	4.6	/	+	+	+
T6	60.3	pT2 m N1	NST⁽*⁾	1 (D2, A2, M1)	3.7 × 3.5 × 2	26.22	1,0	15%	-	+	+
T7	78.6	pT2 N1 Mx	NST⁽*⁾	3 (D2, A3, M3)	2.2 × 1.7 × 1.8	6.7	8.3	30%	-	+	+
T8	35.9	pT2 N0 (sn) (mol)	NST⁽*⁾	3 (D3, A3, M3)	2.3 × 1.8 × 1.6	6.6	11,0	35%	-	+	+
T9	46.6	pT2 N1	NST⁽*⁾	1 (D1, A2, M1)	2.1 × 1.9 × 1.4	5.6	1.2	8%	-	+	+
T10	48.4	pT2 N1 mi (sn) (mol+)	NST⁽*⁾	2 (D3, A2, M2)	2.5 × 2 × 2.3	11.5	3,0	10%	-	+	+
T11	73.1	pT2 N1 Mx	NST⁽*⁾	2 (D3, A2, M2)	3.5 × 3 × 3.2	33.6	4.3	20%	-	+	+
T12	54.0	pT2 N2 Mx	Infiltrating duct carcinoma not otherwise specified (NOS) + Encapsulated papillary carcinoma	3 (D3, A3, M3)	2.7 × 2.7 × 2.5	18.3	11,0	35%	-	+	-
T13	57.6	pT2 N1 mi (mol+)	Infiltrating duct carcinoma not otherwise specified (NOS) + invasive lobular carcinoma	3 (D3, A2, M3)	4.1 × 3.3 × 1.6	21.6	8.3	30%	-	+	+
T15	69.5	pT3 N0 sn (mol-)	Invasive lobular carcinoma	2 (D3, A2, M1)	11 × 7.5 × 6.5	500.5	0.7	12%	-	+	-
T16	78.8	pT2 N0 sn (mol)	Ductal carcinoma in situ (DCIS)	2 (D2, A2, M2)	2.5 × 1 × 1.7	4.3	4.2	15%	-	+	+
T17	45.3	pT2N1mi(sn) (mol+)	NST⁽*⁾	2 (D3 ,A2 ,M1)	2.7 × 2.1 × 2.1	11.9	2,0	15%	-	+	-
T18	80.3	pT2N1mi (sn)(mol+)	Pleomorphic invasive lobular carcinoma	3 (D3, A3, M2)	2.2 × 2.1 × 1.4	6.5	6.3	25%	-	-	-
T19	45.9	ypT3N0	Invasive lobular carcinoma	2 (D3, A2, M1)	6.5 × 2.3 × 6.5	97.2	1.3	18%	-	+	+
T20	44.2	pT2NOsn(mol)	NST⁽*⁾	3 (D3, A2, M2)	2.1 × 2 × 1.8	4.6	4,0	15%	-	+	+

(1) Classification 2017 (American Joint Committee on Cancer (AJCC). AJCC cancer staging manual. 8th ed. (2017) New York, NY: Springer in WHO classification of Tumours − 5th edition- 2019.
(2) Scarff-Bloom-Richardson (SBR): D: differentiation; A: anisokaryosis; M: mitosis [11].
(3) Mitosis number / mm²
(4) Ki67 immunostainning with Dako Mib1.
(5) HER2 immunostainning with Dako A0485 and FISH confirmation (+ if overexpression = 2).
(6) Oestrogen Receptor expression with Dako Sp1.
(6) Progesterone Receptor expression with Dako PqR636.
^(*) NST: Invasive Breast Carcinoma of No Special Type (formerly: Invasive ductal carcinoma)

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