EGFR-dependent aerotaxis is a common trait of breast tumour cells

Mikaelian, Ivan; Gadet, Rudy; Deygas, Mathieu; Bertolino, Philippe; Hennino, Anca; Gillet, Germain; Rimokh, Ruth; Berremila, Sid-Ali; Péoc’h, Michel; Gonzalo, Philippe

doi:10.1186/s13046-022-02514-y

Journal of Experimental & Clinical Cancer Research

Table 3 Characteristics of the cell lines used in this article

From: EGFR-dependent aerotaxis is a common trait of breast tumour cells

Aerotaxis profile	Cell lines	Year of isolation	Source	Tumour Type [40]*	First description	Cell morphology	Karyotype (ATCC, [41], [42]	ER [40]*	PR [40]*	HER2 [40]*	Subtype [40]*	Subtype [43]	Tumorigenic in nude mice **
1	MCF10A	1984	PB	F	[44]	epithelial	48.XX.3-, 6p+, + 8, 9p+,+16 with focal deletions in 3p26.3 and 9p21.3 and focal amplification in 8q24.21 responsible for MYC amplification.	-	-	-	BaB	/	-
	SK-BR-3	1970	PE	AC	[45]	epithelial	Hypertriploid to hypotetraploid (modal number 80 ~ 84). Very numerous structural abnormalities. Three normal X chromosomes in most cells.	-	-	+	Lu	H	+
	BT-549	1978	PB	IDC/Pap	[46]	epithelial	Hypertriploid (modal number 78; range 73 ~ 80) and aneuploid (X chromosomes all abnormal).	-	-	-	BaB	TNB	+ [47]
	BT-474	1978	PB	IDC	[46]	epithelial, patchy	Hypertetraploid (range 65 ~ 106) and aneuploid (XO usually). Numerous numerical and structural abnormalities.	+	+	+	Lu	LB	+
	BT-20	1958	PB	IDC	[48]	epithelial	Diploid cell line (modal number 49 ; range 43 ~ 53). Normal chromosomes N3, N4, N9, N13, N14, and X may be absent.	-	-	-	BaA	TNA	+
	CAL-51	1990	PE	AC	[49]	epithelial-like	Normal karyotype. PIK3CA mutation p.E542	-	-	-	TN	TNB	+ [49]
2	CAMA1	1978	PE	AC	[50]	epithelial	Hypertriploid (modal number 80; range 68 ~ 83) with numerous rearrangements. Paired normal X chromosomes present in every cell.	+	- [40] ± [43]	-	Lu	LA	+
	MCF7	1975	PE	IDC	[51]	epithelial, loosely attached	Hypertriploid to hypotetraploid (modal number 82; range 66 ~ 87). 58 different rearrangements (31 numerical and 27 structural).	+	+	-	Lu	LA	+
	MDA-MB-453	1976	PCE	AC	[52]	epithelial	Hypo- to near-tetraploid (modal number 90; range 87 ~ 91 and aneuploid. Numerous numercial and structural abnormalities. Near-diploid population initially reported replaced by a tetraploid population.	-	-	- [40] + [43]	Lu	H	+ [53]
	MDA-MB-361	1973	BM	AC	[52]	epithelial, loosely attached	Hyperdiploid (modal number 56; range 54 ~ 61) and aneuploid. Numerous structural and numerical abnormalities.	+	± [40] - [43]	+	Lu	LB	+
3	MDA-MB-231	1973	PE	AC	[54]	epithelial	Near triploid (modal number 64, range 52 ~ 68) and aneuploid. Numerous structural abnormalities.	-	-	-	BaB	TNB	+
	MDA-MB-157	1972	PE	AC	[55]	epithelial	Near triploid c(modal number 52 to 54; range 52 ~ 69) with 3 normal X chromosomes. Numerous structural abnormalities on most autosomes.	-	-	-	BaB	TNB	+
	T47D	1974	PE	IDC	[56]	epithelial	Hypotriploid (modal number 65; range 57 ~ 66). Very numerous numerical and structural abnormalities.	+	+	-	Lu	LA	+ [57]
4	Hs578T	1977	PB	IDC	[58]	epithelial, stellar	Hypotriploid (modal number 59) with numerous rearrangements and abnormalities.	-	-	-	BaB	TNB	+ [59] *******
4	MDA-MB-468	1977	PE	AC	[13]	epithelial	Hypotriploid (modal number 64; range 60 ~ 67) and aneuploid (X, abnormal X). Numerous numerical and structural abnormalities.	-	-	-	BaA	TNA	+

Source: PB, Primary, Breast; PE, Pleural effusion; PCE, Pericardial effusion; BM, Brain metastasis. Tumour type: F, fibrocystic disease; AC, adenocarcinoma; IDC, invasive ductal carcinoma; Pap, papillary. Subtype [40]: Lu, Luminal; BaA, BasalA; BaB, Basal B; TN, Triple negative. *Except CAL-51 described in https://www.dsmz.de/collection/catalogue/details/culture/ACC-302. Subtype [43]: LA, luminal A; LB, luminal B; H, HER2 positive; TNA, Triple negative A; TNB, Triple negative B. **according to ATCC or ECAAC, except where a reference is cited. ***https://www.culturecollections.org.uk/products/celllines/generalcell/detail.jsp?refId=86082104%26collection=ecacc_gc

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ISSN: 1756-9966

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