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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

Fig. 4

Increased EMT in PDAC organoid cells induced by CAFs. A Integrated UMAP representation of PDAC organoid cells from monoculture and co-culture samples, with eight clusters distinguished by Louvain clustering. Keywords indicate functional cluster identities based on GO term analysis. B Expression across all PDAC organoid clusters of genes specifically enriched in one cluster. C Volcano plot depicting the fold change and significance of genes differentially expressed in PDAC organoid cells in monocultures compared to co-cultures. D Selected Hallmark (H), Reactome (R) and GO gene sets upregulated in PDAC organoid cells in co-cultures compared to monocultures. E Distribution of EMT scores in PDAC organoid cells, using the same UMAP representation as in (A). F Distribution of EMT scores by cluster in PDAC organoid cells in monocultures (blue) and co-cultures (red). G Expression of EMT-related genes in PDAC organoid cells in monocultures (blue) and co-cultures (red)

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