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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma

Fig. 8

Increased intratumoral CD8+ T cell infiltration after MβCD plus anti-GD2 treatment is mediated by CXCL9 and CXCL10. A Representative images of CD8A, CXCL9, CXCL10, and caveolin-1 immunohistochemical staining of tumors treated with PBS, MβCD, or anti-GD2 mAb (scale bar: 100 μm). B A bar graph showed the IHC score quantification of CXCL9, CXCL10, and caveolin-1. Quantifications of CD8+ T cells percentage from mice treated with different conditions as indicated. C Flow cytometric analysis (left) and statistical analysis (right) of the numbers of CD8+ T cells per mg of tumors in mice 21 days after the beginning of treatments

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