Fig. 2
From: The importance of being CAFs (in cancer resistance to targeted therapies)
Resistance to targeted therapies: the role of soluble factors. Main mechanisms of resistance to molecular therapies mediated by CAF-produced soluble factors and exosomal vescicles are represented. HGF: Hepatocyte Growth Factor; FGF: Fibroblast Growth Factor; IGFs: Insulin-like Growth Factors; PDGF-C: Platelet-Derived Growth Factor C; NRG1b: Neuregulin-1b; IL-6: interleukin 6; sFRP2: secreted frizzled related protein 2; EV: exosomal vesicles; CSC: cancer stem cell