Fig. 4
From: The importance of being CAFs (in cancer resistance to targeted therapies)
Targeting CAF-mediated resistance. Possible strategies for targeting CAFs comprise: A CAF depletion; B CAF differentiation towards fibroblasts; C targeting growth factors or chemokines released by CAFs; D targeting ECM components; E interrupting (dashed red line) the metabolic interplay between CAFs and tumor cells. FAP: fibroblast activating protein; ATRA: all-trans-retinoic acid; SST: somatostatin; GF: growth factors; RTKs: receptor tyrosine kinases; TKIs: tyrosine kinase inhibitors; mAbs: monoclonal antibodies; ECM: extracellular matrix; SHH: sonic hedgehog; SMO: smoothened; LDH: lactate dehydrogenase; MCTs: monocarboxylate transporters