Fig. 7
From: UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis
ALKBH5 regulates UBR7 expression through m6A modification. A UBR7 expression was positively correlated with ALKBH5 expression in an analysis of TCGA data. B-E qRT-PCR and western blot analysis of ALBKH5 and UBR7 upon ALKBH5 silencing or overexpression. F, G RIP-qPCR showed the enrichment of UBR7 m6A upon ALKBH5 silencing or overexpression. H The decay rate of UBR7 mRNA in cells treated with 2.5 mmol/L actinomycin D for indicated times upon ALKBH5 silencing or overexpression. Data are shown as the mean ± SD. *P < 0.05; **P < 0.01