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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Fig. 5

Main URs explaining the immunomodulatory function of guadecitabine. A. Upstream Regulators predicted to be activated (Z score > 2, p value < 0.05, left graph) or inhibited (Z score < − 2, p value < 0.05, right graph), in at least 6/10 cell lines. B. Upstream Regulators predicted to be activated (Z score > 2, p value < 0.05) in up to 5/10 cell lines. Data in A and B based on IPA analysis of NanoString gene modulation data. Color-coded arrows define the biological function/pathway of each UR. Each black dot in the two graphs represents the Z score value of the indicated URs, computed for a single cell line

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