Fig. 1

Synergistic effects of BET and HDAC inhibitors on MB cell growth. A MTT assay showing dose-dependent growth effects of BET inhibitors JQ1 or OTX015 (OTX) and HDAC inhibitor panobinostat (PAN) alone or combined, with the doses as indicated, in MB cell lines at 72 h. Percentage of viable cells is relative to DMSO-(solvent control)-treated cells. Results are the representative of three independent replicates. Plotted values and error bars represent mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.005 (Student-t-test). The asterisks are showing significance between single agents and combinations (JQ1 or PAN vs JQ1-PAN combination; OTX or PAN vs OTX-PAN combination). B Combination index (CI) analysis for the synergism of JQ1/PAN or OTX/PAN in MB cell lines