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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma

Fig. 6

Combined in vivo effects of OTX and PAN in subcutaneous MYC-amplified MB-bearing xenografts. A Tumor volume measurement of xenografted mice following treatments. The differences between treatment groups represent ANOVA-based comparison of the tumor volumes on 21 days post-treatment. B Weight measurement of the tumors (shown in a photo image and plotted in a bar graph) from the last three xenografted mice sacrificed following treatments. Plotted values and error bars represent mean ± SEM. C Representative IHC images (40 × magnification with 60 µm scale bar) of MYC, Ki-67 and cleaved-caspase-3 (CC3) in treated xenografts. D The percentage of MYC, Ki-67 and CC3 positive cells derived from histology scores was semi-quantified in the tumors (shown in Fig. 6B) of three xenografted mice following 21 days post-treatment of inhibitors. *p < 0.05; **p < 0.01; ***p < 0.001 (ANOVA)

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