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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein

Fig. 3

TRIM56 promotes malignant progression of glioma in vivo. a-b In vivo bioluminescence imaging and quantification of xenografts derived from lentivirus-infected GBM#P3 sh-TRIM56-NC, -S1, and -S2 cells at the indicated time points (data from 5 animals/group). Representative bioluminescence images at day 7, day 14, day 21 and day 28 post-implantation are shown. Two-way ANOVA and log rank analysis were used to determine the statistical significance of bioluminescence on day 28 (P1 < 0.0001; P2 < 0.0001). Data are shown as the mean ± SEM. c-d Weight and Kaplan–Meier analysis of survival time for nude mice implanted with the GBM#P3 cells performed at the indicated time points. Data are shown as the mean ± SEM of three independent experiments. Two-way ANOVA and log-rank analysis were used to determine statistical significance (scale bar, 100 Âµm). e Representative images of HE staining of brain sections from xenografted mice on the day of euthanasia, showing representative macroscopic features. Scale bar = 2 mm. f Representative images of immunostaining of TRIM56 and Ki67 in xenograft sections (scale bar, 100 µm). Comparisons between two independent samples and among multiple samples were performed using two-tailed t tests and one/two-way ANOVA, respectively. Error bars indicate at least three independent experiments, and data are shown as mean ± SEM. ∗ p < 0.05, ∗  ∗ p < 0.01, ∗  ∗  ∗ p < 0.001, and ∗  ∗  ∗  ∗ p < 0.0001

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