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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

Fig. 2

Crenigacestat reduced peritumoral fibrosis in two iCCA models. Panel A. PDX iCCA model and Panel B. Hydrodynamic injection iCCA model. Tissue sections were stained using the Azan Mallory’s trichrome staining. Representative images were acquired at 20X magnification. Scale bar represents 50 μm. An adapted METAVIR scoring system was used to quantify the fibrosis in treated and untreated mice, as reported in the graphs

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