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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

Fig. 6

Crenigacestat enhances the chemosensitivity of iCCA to Gemcitabine in the PDX model. At the end of treatment, the tumor volume of the masses was significantly reduced in all treated-mice compared to the vehicle. The combination of Crenigacestat with Gemcitabine improves the efficacy of treatment in iCCA. **p < 0.001, ***p < 0.0001 calculated with Student’s t-test

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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