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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

Fig. 9

Notch inhibitors downregulate TGFβ pathway in iCCA hCAFs. Panel A and C. Crenigacestat and FLI-06 downregulate TGFβ secretion in iCCA hCAFs conditioned media. Panel B and D. pSmad2 was significantly inhibited by both Notch inhibitors; in particular, Crenigacestat induces a dose-dependent inhibition. *p < 0.05, **p < 0.01, ***p < 0.001 calculated with Student’s t-test

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