Fig. 1From: A functional loop between YTH domain family protein YTHDF3 mediated m6A modification and phosphofructokinase PFKL in glycolysis of hepatocellular carcinomaYTHDF3 is overexpressed in tumor samples from HCC patients and high expression of YTHDF3 is correlated with poor prognosis of HCC patients. a Representative immunohistochemical images were shown (left) and YTHDF3 protein expression between surrounding and carcinoma tissues of HCC patients (n = 466) (right). Scale bar 100 μm. b Representative immunohistochemical images were shown (left) and YTHDF3 protein expression between HCC patients in early and middle-late stages (n = 464) (right). Scale bar 100 μm. c Representative immunohistochemical images were shown (left) and YTHDF3 protein expression between HCC patients without or with capsular invasion (n = 466) (right). Scale bar 100 μm. d Representative immunohistochemical images were shown (left) and YTHDF3 protein expression between HCC patients without or with vascular invasion (n = 466) (right). Scale bar 100 μm. e Scatter plot analysis of tumor greatest diameters between YTHDF3 low and high-expression HCC patients. f-g The relative mRNA and protein expression of YTHDF3 in fresh tumor and surrounding tissues of HCC patients. Normalized to β-actin. h Overall survival analysis of HCC patients with low or high expression of YTHDF3 in Sun Yat-Sen Memorial Hospital (upper) and Sun Yat-Sen University Cancer Center (lower). i The background mRNA and protein expression of YTHDF3 in HCC cell lines. Normalized to β-actin. Data are shown as mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001). Arrows indicate the location of positive signal of YTHDF3 proteinBack to article page