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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex

Fig. 6

Nuclear-localized lncRNA ELF3-AS1 regulates cell cycle progression by affecting G1/S transition and histone synthesis. A Subcellular localization of ELF3-AS1 by RNA FISH in GC cell lines. Bar, 10 μm. B The ELF3-AS1 transcripts were mainly located in the nucleus of GC cell lines. C GSEA analysis showed that ELF3-AS1 depletion possessed an obvious effect on cell cycle progression in GC (D) ELF3-AS1 negatively regulated the G1/S transition of the cell cycle in GC. E, F The histone-coding genes significantly regulated by ELF3-AS1 knockdown (|Log2FC|>0.7) were shown in the heat map. Almost all the histone-coding genes were upregulated in the ELF3-AS1-depleted cell lines. G The normalized expression (FPKM value) of CDKN1A, CDK6 and CASP7 after knockdown of ELF3-AS1 in GC cell lines. H The mRNA level of CDKN1A, CDK6 and CASP7 were determined after knockdown of ELF3-AS1. **P < 0.01

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