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Table 3 Concurrent therapy and prognostic factors

From: Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment

 

MGMT

(methylated, not methylated)

IDH

(mutated, not mutated)

Age (years)

(59 or less, > 60)

KPS

(90 or 100, 70 or 80)

No vaccine (n = 3)

1 vs 2

0 vs 3

1 vs 2

2 vs 1

2 or 3 vaccinations, no concurrent therapy (n = 8)

3 vs 5

1 vs 7

4 vs 4

1 vs 7

Concurrent TMZ alone (n = 29)

8 vs 21

4 vs 25

18 vs 11

17 vs 12

Concurrent TMZ + bevacizumab (n = 11)

3 vs 8

2 vs 9

7 vs 4

6 vs 5

Concurrent TMZ + TTF (n = 6)

3 vs 3

0 vs 6

2 vs 4

3 vs 3

Concurrent TMZ + TTF + bevacizumab (n = 3)

1 vs 2

0 vs 3

1 vs 2

2 vs 1

Total (n = 60)

19 vs 41

7 vs 53

33 vs 27

31 vs 29

  1. IDH isocytrate dehydrogenase, MGMT O-6-methylguanine-DNA methyltransferase, TMZ temozolomide, TTF tumor treating fields;